What do we do:
Genomic research

Dr. Agustín Ruiz, Research director

"The main objective of our genomic research group is to understand the causes of Alzheimer's disease and other dementias by integrating genetic, transcriptomic and proteomic data."

GScholar

The gene bank of Fundació ACE is considered one of the largest in the world in the field of dementia, with more than 20,000 samples stored.

Thanks to the existence of this collection, the genomics laboratory of Fundació ACE presents two lines of research focused on:

1) The search for new genetic targets for the treatment of Alzheimer's disease. GR@ACE project.

We have identified 40 genetic risk factors linked to Alzheimer's. However, these findings are still insufficient to establish the exact mechanism by which this disease is generated.

2) The study of the molecular mechanisms of the APOE gene, the main genetic risk factor for Alzheimer's disease. ADAPTED project.

Apolipoprotein Ԑ4 (APOE) is the main genetic risk factor for Alzheimer's. It is present in 45% of the cases although it is unknown how it intervenes in the development of the pathology. The ADAPTED project, designed and led by our team, uses avant-garde technologies, such as the use of genetically modified stem cells, to discover the mechanism of the APOE gene.


On-going projects

GR@ACE - Genomic Research at Fundació ACE

The GR@ACE project is a human genetics study aiming to discover new genes that cause Alzheimer's and use this information to propose new treatments to face the disease.

EXIT - Exosomes Isolation Tool with nanofluidic concentration Device

This research project uses technological advances in the field of nanotechnology and the separation of nanoparticles for the early clinical diagnosis of Alzheimer's disease.

ADAPTED - Alzheimer’s Disease Apolipoprotein Pathology for Treatment Elucidation and Development

ADAPTED is a project that investigates the biological mechanisms through which the presence of the APOE gene increases the risk of developing Alzheimer's.

Estudio de variantes raras en genes asociados a Enfermedad de Alzheimer en la población española

This project wants to study in depth and detect rare genetic variants associated with Alzheimer's. This is the first genomic study conducted in our country to address this issue specifically in Alzheimer's disease.